The MTHFR guardrail (and why it matters)
MTHFR variants (notably C677T and A1298C) are the most over-interpreted finding in consumer nutrigenomics. The internet is full of advice telling people with a single MTHFR SNP to permanently avoid folic acid, megadose methylfolate, or restructure their diet around one variant. PlateHelix is explicitly not an MTHFR absolutist. A single SNP shifts our suggestions toward folate-rich whole foods (leafy greens, legumes, citrus). It does not declare hard food bans, prescribe supplements, or override your clinician. The same logic applies to COMT, APOE, FUT2, and every other variant we surface.